A stochastic model of the dynamics of HIV under a combination therapeutic intervention

  • VSS Yadavalli Department of Industrial and Systems Engineering, University of Pretoria
  • MMO Labeodan Department of Statistics, University of Pretoria
  • S Udayabaskaran Vel Tech Dr RR & Dr SR Technical University No. 42
  • Y Mwanga Institute of Statistics and Economics, Makerere University


Drug resistance to single therapeutic treatment in HIV infected individuals has promoted research into combined treatments. In this paper we propose a stochastic model under combined therapeutic treatment by extending the model of HIV pathogenesis under treatment by anti-viral drugs given in [Perelson AS, Neumann AU, Markowits M, Leonard JM & Ho DD, 1996, "HIV-1 dynamics in vivo virion clearance rate, infected cell life span, and viral generation time", Science New Series, 271, pp. 1582-1586]. Variance and co-variance structures of variables are obtainable via this approach in addition to the mean numbers of free HIV, infectious free HIV and non-infectious free HIV that were obtained by Perelson et al. Comparing simulated data for before and after treatment indicates the importance of combined treatment and its overall effect(s).
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